Texas Tech fell behind 8-1 in the first three innings and could not overcome the early deficit in its 16-5 loss to New Mexico Tuesday in Albuquerque.
John Henry Gonzalez gave up eight runs in 2.1 innings of work.
Grant Little’s first home run of the season pulled the Red Raiders within five runs in the the seventh but the Lobos would answered with a six-run eighth inning to pull away for good.
Texas Tech (33-11) have now lost back-to-back games for the first time this season.
The same two teams meet again at 2 p.m. Wednesday at Santa Ana Star Field.