The Red Raiders dropped their first game of the season to the Cowboys on Saturday at the Jones 41-34.
Oklahoma State quarterback Mason Rudolph ran 16 yards for the go-ahead touchdown in the final two minutes to win the game.
Texas Tech was held to a season low of 394 yards of total offense. Nic Shimonek finished the night 29 of 46, 330 yards and one touchdown.
The Red Raiders will turn their attention to Kansas on October 7 at 11 a.m. in Lawrence.